Acetone Cyanohydrin → HCID 56968103, compound

Participants

Reaction Steps

To a stirred solution of 8,8-dimethyl-5-[1-(2-trifluoromethyl-phenyl)-meth-(Z)-ylidene]-5,8-dihydro-pyrano[3,4-b]pyrazin-7-one (0.170 g) in acetonitrile (1.7 ml) at ambient temperature was added triethylamine (0.154 g) and 4□ molecular sieves. After 10 min acetone cyanohydrin (0.013 g) was added and the reaction mixture stirred for 16 hours. The reaction mixture was concentrated and the residue purified by chromatography on silica gel (eluent 5-95% ethyl acetate in isohexane) to give the crude 8,8-dimethyl-6-(2-trifluoromethyl-phenyl)-8H-quinoxaline-5,7-dione (compound E1 of Table E) (0.190 g) which was carried over to the next step.

Provenance & Evidence