反应详情

温度

40 °C

To a solution of 2-({3-[2-(2-aminopyridin-3-yl)-3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3H-imidazo[4,5-b]pyridin-5-yl]phenyl}amino)-1,1-dimethyl-2-oxoethyl acetate (24 mg) in methanol (6 mL) was added MP-carbonate (Argonaout technologies 2.91 mmol/g, 200 mg) at room temperature. After being stirred at 40° C. for 4 h, the reaction mixture was filtered and concentrated under reduced pressure. Purification by column chromatography (0-10% methanol in chloroform) gave the product (20 mg, 91%).

1. filtrationthe reaction mixture was filtered
2. concentrationconcentrated under reduced pressure
3. customPurification by column chromatography (0-10% methanol in chloroform)