1,3-Dibromobenzene → HCID 71138448, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1,3-dibromobenzene (242 μL, 2.00 mmol), cis-2,6-dimethylmorpholine (248 μL, 2.00 mmol), Pd2(dba)3 (45.8 mg, 0.0500 mmol), rac-BINAP (96.3 mg, 0.150 mmol) and NaOtBu (231 mg, 2.40 mmol) in toluene was heated at 80° C. for 11 hours under nitrogen. After cooling to room temperature, the mixture was diluted with DCM and filtered through a Celite pad. The combined filtrate and washings were concentrated. The residue was purified by silica gel column chromatography (EtOAc/hexane=98:2→97:3) to afford desired product (356 mg, 65.8%) as pale yellow oil.

Provenance & Evidence