反应详情

To a solution of 7-(1-methyl-1H-pyrazol-4-yl)-5-(1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine (Preparation; K-1; 0.130 g, 0.490 mmol) in dry DMF (2 mL) was added DBU (89.5 mg, 0.588 mmol) and 3-cyclopropylacrylonitrile (Preparation B; 0.183 g, 1.96 mmol). The reaction mixture was stirred at ambient temperature for 24 hours. Additional 3-cyclopropylacrylonitrile (0.046 g, 0.49 mmol) was added and the reaction mixture was stirred at ambient temperature for 72 hours. The reaction mixture was added to H2O (8 mL), mixed and extracted with EtOAc. The combined EtOAc extracts were washed with saturated NaCl and dried over MgSO4/activated carbon. The solution was eluted through a short SiO2 column (15 mL course frit funnel, ½ full of SiO2) eluting first with EtOAc, then with 10% MeOH/EtOAc. The 10% MeOH/EtOAc fraction was concentrated and the resulting residue treated with Et2O and sonicated to give a granular suspension. The precipitate was allowed to settle, Et2O decanted off, solid washed with Et2O and then dried under vacuum to provide a 3-cyclopropyl-3-(4-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)propanenitrile (40 mg, 23% yield) as a white powder. MS (apci) m/z=359.2 (M+H).

1. stirringthe reaction mixture was stirred at ambient temperature for 72 hours
2. additionmixed
3. extractionextracted with EtOAc
4. washThe combined EtOAc extracts were washed with saturated NaCl
5. dry with materialdried over MgSO4/activated carbon
6. washThe solution was eluted through a short SiO2 column (15 mL course frit funnel, ½ full of SiO2)
7. washeluting first with EtOAc
8. concentrationThe 10% MeOH/EtOAc fraction was concentrated
9. additionthe resulting residue treated with Et2O
10. customsonicated
11. customto give a granular suspension
12. customEt2O decanted off
13. washsolid washed with Et2O
14. customdried under vacuum