反应详情

2-methyl-5-(5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-7-yl)thiazole (0.196 g, 0.475 mmol) was dissolved in 3 mL of DCM before TFA (2.0 mL, 26.0 mmol) was added slowly at room temperature. The reaction was allowed to stir at room temperature for 8 hours. The reaction mixture was concentrated under reduced pressure to afford the crude material. The crude material was purified via column chromatography, eluting with 5% MeOH in DCM with 1% NH4OH to afford the title compound (0.087 g, 64.9% yield). MS (apci) m/z=283.1 (M+H).

1. additionwas added slowly at room temperature
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customto afford the crude material
4. customThe crude material was purified via column chromatography
5. washeluting with 5% MeOH in DCM with 1% NH4OH