反应详情

温度

100 °C

4-(4-(5-(methylthio)imidazo[1,2-c]pyrimidin-7-yl)phenyl)morpholine (0.4000 g, 1.225 mmol) and potassium hydroxide (1.021 mL, 6.127 mmol) were suspended in DMSO (3 mL) and heated at 100° C. for 1.5 hours in a microwave. The reaction mixture was diluted with water (40 mL) and acidified with acetic acid (1.052 mL, 18.38 mmol). The resulting solids were collected by filtration and dried under high vacuum to afford 7-(4-morpholinophenyl)imidazo[1,2-c]pyrimidin-5(6H)-one (0.3460 g, 95.28% yield). MS (apci) m/z=297.2 (M+H).

1. filtrationThe resulting solids were collected by filtration
2. customdried under high vacuum