Hydrochloric Acid → HCID 67458429, compound

Participants

Reaction Steps

Tert-butyl 3-(cyanomethyl)-3-(3-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate (Example 129; 28.3 mg, 0.0616 mmol) was dissolved in DCM (308 μL, 0.0616 mmol) and treated with 4N HCl in dioxane (308 μL, 1.23 mmol). The reaction mixture was stirred at ambient temperature for 1 hour, then concentrated in vacuo to afford 2-(3-(3-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile hydrochloride (14.3 mg, 53.7% yield) as a white solid. MS (apci) m/z=360.2 (M+H).

Provenance & Evidence