Diisopropylethylamine → HCID 68230800, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 3-(cyanomethyl)-3-(4-(7-(2-methoxypyrimidin-5-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate (150 mg, 0.308 mmol) was dissolved in MeOH (5 ml) and a 4M HCl/dioxane solution (5 mL) was added. The resulting mixture was stirred for 20 minutes and then was concentrated to a solid. To the solid was added dichloromethane (15 mL) and diisopropyl ethylamine (787 μL, 4.52 mmol). After 10 minutes, the resulting mixture was cooled to −40° C. and cyclopropanesulfonyl chloride (43.3 mg, 0308 mmol) was added. The reaction mixture was allowed to come to ambient temperature overnight. The resulting mixture was concentrated to an oil and the oil was chromatographed to yield 70.8 mg (46.8%) of the title compound. MS (apci) m/z=509.0 (M+H).

Provenance & Evidence