Trifluoroacetic acid → HCID 86685339, compound

Participants

Reaction Steps

tert-Butyl 3-(cyanomethyl)-3-(4-(7-(1-(oxetan-3-yl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate (0.75 g, 1.5 mmol) was suspended in DCM (15 mL) and TFA (5 mL) and stirred at ambient temperature for 2 hours. The reaction mixture was diluted with toluene and concentrated under reduced pressure. The material was transferred to another flask with DCM and MeOH and concentrated under reduced pressure to afford the crude 2-(3-(4-(7-(1-(oxetan-3-yl)-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidin-5-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile bis(2,2,2-trifluoroacetate) (1.31 g, 1.46 mmol, 97.4% yield), which was used in the next step without further purification.

Provenance & Evidence