Piperidine → HCID 66546510, compound

Participants

Reaction Conditions

Reaction Steps

The compound prepared in Example 36 (80 mg) and piperidine (0.300 mg) were mixed in DMSO (0.400 mL) and heated to 120° C. for 18 hours. The reaction mixture was then diluted with MeCN (10 mL) and aqueous 1M K2CO3 (7 mL) and heated to 155° C. for 17 minutes in the microwave. The organic products were extracted with EtOAc/CH2Cl2 (9:1) and washed with brine. The material was purified by HPLC (H2O/MeCN with 0.1% TFA). The solvent was removed and the residue was dissolved in CH2Cl2 and the residual TFA was removed by PL-HCO3 MP SPE ion exchange column to give the title compound (10 mg) having the following physical data.

Provenance & Evidence