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HRID1853176

反应详情

EQUATION

反应方程式

HRID 1853176 的结构方程式

REACTANTS

反应物

2
结构：CS(=O)(=O)N1CCNCC1
HCID709161

未命名化合物

结构：CN(C)C(=O)c1cc2cnc(Nc3ccc(C=O)cn3)nc2n1C1CCCC1
HCID58315440

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)C(=O)c1cc2cnc(Nc3ccc(CN4CCN(S(C)(=O)=O)CC4)cn3)nc2n1C1CCCC1
HCID58315434

未命名化合物

PROCEDURE

实验过程

Following General Procedure B, 7-cyclopentyl-2-(5-formyl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (150 mg, 0.396 mmol) and 1-methanesulfonyl-piperazine (72 mg, 0.436 mmol) gave 7-cyclopentyl-2-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-pyridin-2-ylamino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide as an off white solid (97 mg, 46%) [following SiO2 chromatography, eluting with 0-10% (2M NH3 in MeOH)/DCM].