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HRID1853177

反应详情

EQUATION

反应方程式

HRID 1853177 的结构方程式

REACTANTS

反应物

2
反应SMILES：CC(=O)N1CCNCC1
HCID83795

1-Acetylpiperazine

C6H12N2O

反应SMILES：CN(C)C(=O)c1cc2cnc(Nc3ccc(C=O)cn3)nc2n1C1CCCC1
HCID58315440

未命名化合物

PRODUCTS

产物

1
反应SMILES：CC(=O)N1CCN(Cc2ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc2)CC1
HCID58315399

未命名化合物

PROCEDURE

实验过程

Following General Procedure B, 7-cyclopentyl-2-(5-formyl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (200 mg, 0.528 mmol) and 1-acetyl piperazine (75 mg, 0.581 mmol) gave 2-[5-(4-acetyl-piperazin-1-ylmethyl)-pyridin-2-ylamino]-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide as an off white solid (96 mg, 37%) [following SiO2 chromatography, eluting with 0-10% (2M NH3 in MeOH)/dichloromethane].