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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1853202생성일: 2026년 10월 25일

2-Bromopropan-1-ol → 7-cyclopentyl-2-{5-[4-(2-hydroxy-1-methyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

https://huagongshe.com/reaction/1853202

반응식

참여 물질

역할이름HCID투입량
반응물2-Bromopropan-1-olHCID 11713—
반응물RibociclibHCID 44631912—
생성물7-cyclopentyl-2-{5-[4-(2-hydroxy-1-methyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamideHCID 4481876225%

반응 단계

Following General Procedure D, 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (100 mg, 0.230 mmol) and 2-bromo propan-1-ol (96 mg, 0.690 mmol) gave 7-cyclopentyl-2-{5-[4-(2-hydroxy-1-methyl-ethyl)-piperazin-1-yl]-pyridin-2-ylamino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (28 mg, 25%). MS (ESI) m/z 493.4 (M+H)+

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08962630B2
출처 데이터셋uspto-grants-2015_02
ORD IDord-bea61d3b295444e98fb573110c756577
출처 메모uspto-grants-2015_02