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HRID1853207

反应详情

EQUATION

反应方程式

HRID 1853207 的结构方程式

REACTANTS

反应物

2
结构：CCC(C)CBr
HCID25254

Butane, 1-bromo-2-methyl-

C5H11Br

结构：CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1
HCID44631912

Ribociclib

C23H30N8O

PRODUCTS

生成物

1
结构：CCC(C)CN1CCN(c2ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc2)CC1
HCID44820016

未命名化合物

收率 43.1%

PROCEDURE

实验过程

Following General Procedure D, 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (100 mg, 0.230 mmol) and 1-bromo-2-methyl butane (103 mg, 0.690 mmol) gave 7-cyclopentyl-2-{5-[4-(2-methyl-butyl)-piperazin-1-yl]-pyridin-2-ylamino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (50 mg, 42%).