HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoacetamide → HCID 44818221, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoacetamide | HCID 69632 | — |
| Reactant | Ribociclib | HCID 44631912 | — |
| Product | HCID 44818221 | HCID 44818221 | 45% |
Reaction Steps
Following General Procedure D, 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (100 mg, 0.230 mmol) and 2-bromo acetamide (95 mg, 0.690 mmol) gave 2-[5-(4-carbamoylmethyl piperazin-1-yl)-pyridin-2-ylamino]-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (50 mg, 45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962630B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-fb1b112526284e398a1b424666d07fe8 |
| Source note | uspto-grants-2015_02 |