O-tert-butylhydroxylamine hydrochloride → HCID 86673021, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-isoquinolin-3-yl-chromen-4-one (459 mg, 1.67 mmol) in methanol (11 ml) was added O-tert-butyl hydroxylamine hydrochloride (421 mg, 3.35 mml). The mixture was heated to 130° C. under microwave irradiation for 30 min. The volatiles were removed by vacuum distillation and the residue was purified by flash chromatography (cyclohexane/ethyl acetate 95/5) to yield 2-isoquinolin-3-yl-chromen-4-one O-tert-butyl-oxime (387 mg, 67%) as a yellow solid.

Provenance & Evidence