O-tert-butylhydroxylamine hydrochloride → HCID 86673023, compound

Participants

Reaction Steps

7-bromo-2-isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime was prepared using the method D (step 1) illustrated in example 1B. 7-bromo-2-isoquinolin-3-yl-chromen-4-one (682 mg, 1.94 mmol) was treated with O-tert-butyl-hydroxylamine hydrochloride (486 mg, 3.87 mmol) in methanol (9 ml) under microwave irradiation to yield 7-bromo-2-isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime (629 mg, 77%) as a yellow solid after purification by flash chromatography over silica gel (cyclohexane/ethyl acetate: 50/50).

Provenance & Evidence