HCID 86673023, compound → HCID 136352218, compound

Participants

Reaction Steps

7-bromo-2-isoquinolin-3-yl-chromen-4-one oxime was prepared using the method D, (step 2) illustrated in example 1C. 7-bromo-2-isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime (150 mg, 0.35 mmol) was treated with a 1M solution of titanium tetrachloride (1.1 ml, 1.1 mmol) in dichloromethane (7.5 ml) to yield 7-bromo-2-isoquinolin-3-yl-chromen-4-one oxime (56 mg, 37%) as a beige solid after recrystallization in hot chloroform. The product was isolated as a 90/10 mixture of Z/E oxime isomers.

Provenance & Evidence