O-tert-butylhydroxylamine hydrochloride → HCID 86673023, compound

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Reaction Steps

7-bromo-2-isoquinolin-3-yl-6-methyl-chromen-4-one O-tert-butyl oxime was prepared using the method D (step 1) illustrated in example 1B. 7-bromo-2-isoquinolin-3-yl-6-methyl-chromen-4-one (730 mg, 1.98 mmol) was treated with O-tert-butyl-hydroxylamine hydrochloride (500 mg, 3.98 mmol) in methanol (13 ml) under microwave irradiation to yield 7-bromo-2-isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime (383 mg, 44%) as a yellow solid after purification by flash chromatography over silica gel (cyclohexane/Chloroform/ethyl acetate: 96/4/0; 50/50/0; 0/100/0 0/50/50).

Provenance & Evidence