HCID 86673027, compound → HCID 136352220, compound

Participants

Reaction Steps

6-bromo-2-isoquinolin-3-yl-chromen-4-one oxime was prepared using the method D, (step 2) illustrated in example 1C. 6-bromo-2-isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime (50 mg, 0.12 mmol) was treated with a 1M solution of titanium tetrachloride (0.35 ml, 0.35 mmol) in dichloromethane (3 ml) to yield 6-bromo-2-isoquinolin-3-yl-chromen-4-one oxime (37 mg, 85%) as a yellow solid after recrystallization in hot chloroform. The compound was isolated as a 98/2 mixture of Z/E oxime isomers.

Provenance & Evidence