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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1853259Generated: October 25, 2026

Methyl 2-acetamidoacrylate → Methyl 6-methylisoquinoline-3-carboxylate

https://huagongshe.com/reaction/1853259

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-acetamidoacrylateHCID 98644—
Reactant2-Bromo-4-methylbenzaldehydeHCID 4645292—
ProductMethyl 6-methylisoquinoline-3-carboxylateHCID 2224364450%

Reaction Steps

methyl 6-methyl-isoquinoline-3-carboxylate was prepared using the procedure described in example 12A: 2-bromo-4-methylbenzaldehyde was reacted with methyl 2-acetamidoacrylate at 110° C. for 18 hours to yield methyl 6-methyl-isoquinoline-3-carboxylate (50%) as brown solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08962627B2
Source datasetuspto-grants-2015_02
ORD IDord-ed8c84d3d8f7478eac387d95047051c1
Source noteuspto-grants-2015_02