HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-acetamidoacrylate → Methyl 7-chloroisoquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-acetamidoacrylate | HCID 98644 | — |
| Reactant | 2-Bromo-5-chlorobenzaldehyde | HCID 15391279 | — |
| Product | Methyl 7-chloroisoquinoline-3-carboxylate | HCID 17842489 | 25% |
Reaction Steps
methyl 7-chloro-isoquinoline-3-carboxylate was prepared using the procedure described in example 12A: 2-bromo-5-chlorobenzaldehyde was reacted with methyl 2-acetamidoacrylate at 110° C. for 24 hours to yield methyl 7-chloro-isoquinoline-3-carboxylate (25%) as brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962627B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-ffda6479c38f4da3a4e42b85c693c17d |
| Source note | uspto-grants-2015_02 |