2-Bromoethyl methyl ether → HCID 136352231, compound

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Reaction Steps

2-isoquinolin-3-yl-6-(2-methoxy-ethoxy)-chromen-4-one oxime was prepared in 67% overall yield using the method described in example 42 and 42A, starting from 6-hydroxy-2-isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime (example 41A) and bromoethylmethylether instead of iodomethane. The title compound was isolated as a yellow solid after purification by flash chromatography over silica gel (cyclohexane/ethyl acetate: 0-80%), and as a 85/15 mixture of Z/E oxime isomers.

Provenance & Evidence