1-(3-Aminopropyl)-4-methylpiperazine → HCID 136352232, compound

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Reaction Steps

2-isoquinolin-3-yl-6-[3-(4-methyl-piperazin-1-yl)-propylamino]-chromen-4-one oxime was prepared in 85% overall yield using the method described in examples 35 and 35A, starting from 6-bromo-2-isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime (example 4B) and 3-(4-methyl-piperazin-1-yl)-propylamine. The title compound was isolated as a yellow solid and as a 95/5 mixture of Z/E oxime isomers.

Provenance & Evidence