1-(2-Hydroxyethyl)-4-methylpiperazine → HCID 136352235, compound

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Reaction Steps

2-Isoquinolin-3-yl-7-{3-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenylethynyl}-chromen-4-one oxime was prepared in 9% overall yield using the method described in examples 44 and 44A, starting from 7-(3-hydroxyphenyl)ethynyl-2-isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime (tert-butyl protected oxime of example 30) and 2-(4-methyl-piperazin-1-yl)-ethanol. The title compound was isolated as a yellow solid and as a 90/10 mixture of Z/E oxime isomers after Preparative HPLC purification (gradient 65-50% Water/acetonitrile+0.05% trifluoroacetic acid).

Provenance & Evidence