2-Bromoethyl methyl ether → HCID 136352237, compound

Participants

Reaction Steps

2-Isoquinolin-3-yl-7-[3-(2-methoxy-ethoxy)-prop-1-ynyl]-chromen-4-one oxime was prepared in 7% overall yield using the methods described in examples 42 and 42A, starting from 7-(3-hydroxy-prop-1-ynyl)-2-Isoquinolin-3-yl-chromen-4-one O-tert-butyl oxime (example 54A) and bromoethylmethylether. The title compound was isolated as a beige solid and as a 90/10 mixture of Z/E oxime isomers after triturating in diethyl ether.

Provenance & Evidence