2'-Hydroxypropiophenone → HCID 67195807, compound

HRID 1853298Notes

Reaction equation

HRID 1853298 reaction equation
O[C:2]1[CH:7]=[CH:6][CH:5]=C[C:3]=1[C:8](=[O:11])[CH2:9][CH3:10].[CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[C:14]([C:22]([O:24][CH3:25])=O)[N:13]=1>>[CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[C:14]([C:22]2[O:24][C:25]3[C:3]([C:8](=[O:11])[C:9]=2[CH3:10])=[CH:2][CH:7]=[CH:6][CH:5]=3)[N:13]=1

Participants

3

Reactant 2

HCID 691332'-HydroxypropiophenoneHCID 725374Methyl 3-isoquinolinecarboxylate

Product 1

HCID 67195807HCID 67195807, compoundYield 76%

Procedure

2-Isoquinolin-3-yl-3-methyl-chromen-4-one was prepared in 76% yield using method A, starting from 2′-hydroxy-propiophenone and methyl isoquinoline-3-carboxylate.

Sources & evidence

ORD record
ord-ec4696bd7da14ff1b73b683809990233
Source dataset
uspto-grants-2015_02
Patent number
US08962627B2

Reaction notes

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