3-Methoxypropyne → HCID 86673071, compound

HRID 1853302Notes

Reaction equation

[C:1]([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14](Br)[CH:15]=2)[O:10][C:9]([C:18]2[N:23]=[CH:22][N:21]3[CH:24]=[CH:25][CH:26]=[C:20]3[CH:19]=2)=[CH:8]1)([CH3:4])([CH3:3])[CH3:2].[CH3:27][O:28][CH2:29][C:30]#[CH:31]>>[C:1]([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:31]#[C:30][CH2:29][O:28][CH3:27])[CH:15]=2)[O:10][C:9]([C:18]2[N:23]=[CH:22][N:21]3[CH:24]=[CH:25][CH:26]=[C:20]3[CH:19]=2)=[CH:8]1)([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 693933-Methoxypropyne

HCID 86673084HCID 86673084, compound

Product 1

HCID 86673071HCID 86673071, compoundYield 39%

Procedure

6-(3-Methoxy-prop-1-ynyl)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl-oxime was prepared in 39% yield using the procedure described in example 23A, starting from 6-bromo-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime (tert-butyl protected oxime of example 66) and 3-Methoxy-propyne. The title compound was isolated as a yellow solid.

Sources & evidence

ORD record: ord-dead330cf08b48f5b2dc9c442158cfab
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08962627B2

Reaction notes

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