Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1853311Generated: November 1, 2026

1-Methylhomopiperazine → 6-[2-(4-Methyl-[1,4]diazepan-1-yl)-ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, dihydrochloride

https://huagongshe.com/reaction/1853311

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-MethylhomopiperazineHCID 228349—
Reactant6-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oximeHCID 86673076—
Product6-[2-(4-Methyl-[1,4]diazepan-1-yl)-ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, dihydrochlorideHCID 131732471—

Reaction Steps

6-[2-(4-methyl-[1,4]diazepan-1-yl)-ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, dihydrochloride was prepared in 13% overall yield using the method described in example 87, starting from 6-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime (example 87B) and 1-methyl-[1,4]diazepane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08962627B2
Source datasetuspto-grants-2015_02
ORD IDord-d18383380d7541a6b2e664c64bb5c83f
Source noteuspto-grants-2015_02