HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-2-(Methoxymethyl)pyrrolidine → 6-[2-((R)-2-methoxymethylpyrrolidin-1-yl)-ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-2-(Methoxymethyl)pyrrolidine | HCID 671216 | — |
| Reactant | 6-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime | HCID 86673076 | — |
| Product | 6-[2-((R)-2-methoxymethylpyrrolidin-1-yl)-ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, hydrochloride | HCID 131732473 | — |
Reaction Steps
6-[2-((R)-2-methoxymethylpyrrolidin-1-yl)-ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, hydrochloride was prepared in 33% overall yield using the method described in example 87, starting from 6-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime (example 87B) and 2-((R)-2-methoxymethylpyrrolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962627B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-9ed80ec5a4d6435fb909def358ed801e |
| Source note | uspto-grants-2015_02 |