HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Chloroethyl)-4-fluorobenzene → 6-[2-(4-Fluoro-phenyl)-ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Chloroethyl)-4-fluorobenzene | HCID 67622 | — |
| Reactant | 6-Hydroxy-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl-oxime | HCID 86673073 | — |
| Product | 6-[2-(4-Fluoro-phenyl)-ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, hydrochloride | HCID 131732481 | — |
Reaction Steps
6-[2-(4-fluoro-phenyl)-ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, hydrochloride was prepared in 9% overall yield using the method described in example 85, starting from 6-hydroxy-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime (example 81A) and 1-(2-Chloroethyl)-4-fluoro-benzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962627B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-d3230f6f46764c5e999c00954acb7ad1 |
| Source note | uspto-grants-2015_02 |