HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane hydrobromide → 6-[(1S,4S)-2-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane hydrobromide | HCID 11159293 | — |
| Reactant | 6-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime | HCID 86673076 | — |
| Product | 6-[(1S,4S)-2-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, hydrochloride | HCID 131732482 | — |
Reaction Steps
6-[(1S,4S)-2-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, hydrochloride was prepared in 37% overall yield using the method described in example 87, starting from 6-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime (example 87B) and (1S,4S)-2-oxa-5-aza-bicyclo[2.2.1]heptane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962627B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-8dcd2647d25b4bf4bd8a2095cae25e0f |
| Source note | uspto-grants-2015_02 |