1,4'-Bipiperidine → HCID 131732486, compound

HRID 1853332Notes

Reaction equation

HRID 1853332 reaction equation
C([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][CH2:19][Cl:20])[CH:15]=2)[O:10][C:9]([C:21]2[N:26]=[CH:25][N:24]3[CH:27]=[CH:28][CH:29]=[C:23]3[CH:22]=2)=[CH:8]1)(C)(C)C.[CH2:30]1[CH2:35][CH2:34][N:33]([CH:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)[CH2:32][CH2:31]1>>[ClH:20].[ClH:20].[N:33]1([CH:36]2[CH2:41][CH2:40][N:39]([CH2:19][CH2:18][O:17][C:14]3[CH:15]=[C:16]4[C:11](=[CH:12][CH:13]=3)[O:10][C:9]([C:21]3[N:26]=[CH:25][N:24]5[CH:27]=[CH:28][CH:29]=[C:23]5[CH:22]=3)=[CH:8][C:7]4=[N:6][OH:5])[CH2:38][CH2:37]2)[CH2:34][CH2:35][CH2:30][CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 786071,4'-BipiperidineHCID 866730766-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime

Product 1

HCID 131732486HCID 131732486, compound

Procedure

6-(2-[1,4′]bipiperidinyl-1′-yl-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, dihydrochloride was prepared in 34% overall yield using the method described in example 87, starting from 6-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime (example 87B) and N-(4-piperidino)piperidine.

Workup

  1. customoverall yield

Sources & evidence

ORD record
ord-fcb2111f8ccb4c909c182a62f978812e
Source dataset
uspto-grants-2015_02
Patent number
US08962627B2

Reaction notes

Loading…