4-(1-Pyrrolidinyl)piperidine → HCID 131732488, compound

HRID 1853334Notes

Reaction equation

HRID 1853334 reaction equation
C([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][CH2:19][Cl:20])[CH:15]=2)[O:10][C:9]([C:21]2[N:26]=[CH:25][N:24]3[CH:27]=[CH:28][CH:29]=[C:23]3[CH:22]=2)=[CH:8]1)(C)(C)C.[N:30]1([CH:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)[CH2:34][CH2:33][CH2:32][CH2:31]1>>[ClH:20].[ClH:20].[N:30]1([CH:35]2[CH2:40][CH2:39][N:38]([CH2:19][CH2:18][O:17][C:14]3[CH:15]=[C:16]4[C:11](=[CH:12][CH:13]=3)[O:10][C:9]([C:21]3[N:26]=[CH:25][N:24]5[CH:27]=[CH:28][CH:29]=[C:23]5[CH:22]=3)=[CH:8][C:7]4=[N:6][OH:5])[CH2:37][CH2:36]2)[CH2:34][CH2:33][CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 866730766-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime

Product 1

HCID 131732488HCID 131732488, compound

Procedure

6-[2-(4-pyrrolidin-1-yl-piperidin-1-yl)-ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime, dihydrochloride was prepared in 90% overall yield using the method described in example 87, starting from 6-(2-chloro-ethoxy)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime (example 87B) and 4-(1-pyrrolidinyl)piperidine.

Workup

  1. customoverall yield

Sources & evidence

ORD record
ord-fe60abcd5dba47778ee7f936ab2c9005
Source dataset
uspto-grants-2015_02
Patent number
US08962627B2

Reaction notes

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