3-(Dimethylamino)propyl chloride hydrochloride → HCID 67195485, compound

HRID 1853336Notes

Reaction equation

HRID 1853336 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:19]=[C:18]3[C:13]([C:14](=[O:29])[CH:15]=[C:16]([C:20]4[N:25]=[CH:24][N:23]5[CH:26]=[CH:27][CH:28]=[C:22]5[CH:21]=4)[O:17]3)=[CH:12][CH:11]=2)[CH:5]=[CH:6][CH:7]=1.Cl.Cl[CH2:32][CH2:33][CH2:34][N:35]([CH3:37])[CH3:36]>>[CH3:36][N:35]([CH3:37])[CH2:34][CH2:33][CH2:32][O:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:19]=[C:18]3[C:13]([C:14](=[O:29])[CH:15]=[C:16]([C:20]4[N:25]=[CH:24][N:23]5[CH:26]=[CH:27][CH:28]=[C:22]5[CH:21]=4)[O:17]3)=[CH:12][CH:11]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 943083-(Dimethylamino)propyl chloride hydrochlorideHCID 67192998HCID 67192998, compound

Product 1

HCID 67195485HCID 67195485, compoundYield 52%

Procedure

7-[3-(3-dimethylamino-propoxy)-phenylethynyl]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one was prepared in 52% yield using the method described in example 42, starting from 7-(3-hydroxy-phenylethynyl)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one (example 120B) and (3-Chloro-propyl)-dimethyl-amine hydrochloride.

Sources & evidence

ORD record
ord-a91c386d5dfe4eb9ad02ee619d340f99
Source dataset
uspto-grants-2015_02
Patent number
US08962627B2

Reaction notes

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