m-Ethynylphenol → HCID 67192998, compound

HRID 1853337Notes

Reaction equation

Br[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:21])[CH:7]=[C:8]([C:12]3[N:17]=[CH:16][N:15]4[CH:18]=[CH:19][CH:20]=[C:14]4[CH:13]=3)[O:9]2)=[CH:4][CH:3]=1.[OH:22][C:23]1[CH:24]=[C:25]([C:29]#[CH:30])[CH:26]=[CH:27][CH:28]=1>>[OH:22][C:23]1[CH:24]=[C:25]([C:29]#[C:30][C:2]2[CH:11]=[C:10]3[C:5]([C:6](=[O:21])[CH:7]=[C:8]([C:12]4[N:17]=[CH:16][N:15]5[CH:18]=[CH:19][CH:20]=[C:14]5[CH:13]=4)[O:9]3)=[CH:4][CH:3]=2)[CH:26]=[CH:27][CH:28]=1

Participants

Reactant 2

HCID 139144m-Ethynylphenol

HCID 67193719HCID 67193719, compound

Product 1

HCID 67192998HCID 67192998, compoundYield 71%

Procedure

7-(3-hydroxy-phenylethynyl)-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one was prepared in 71% yield using the method described in example 23A, starting from 7-bromo-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one (example 120C) and 3-hydroxyphenylacetylene. The title compound was isolated as a brown powder.

Sources & evidence

ORD record: ord-56793288940943a5b4fcf7eb38b07ead
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08962627B2

Reaction notes

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