HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → 6-(2-Morpholin-4-yl-ethoxy)-2-pyrrolo[1,2-a]pyrazin-3-yl-chromen-4-one O-tert-butyl-oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| Reactant | 6-Hydroxy-2-pyrrolo[1,2-a]pyrazin-3-yl-chromen-4-one O-tert-butyl-oxime | HCID 86673097 | — |
| Product | 6-(2-Morpholin-4-yl-ethoxy)-2-pyrrolo[1,2-a]pyrazin-3-yl-chromen-4-one O-tert-butyl-oxime | HCID 86673096 | 68% |
Reaction Steps
6-(2-Morpholin-4-yl-ethoxy)-2-pyrrolo[1,2-a]pyrazin-3-yl-chromen-4-one O-tert-butyl-oxime was prepared in 68% yield using the procedure described in example 85A, starting from 6-Hydroxy-2-pyrrolo[1,2-a]pyrazin-3-yl-chromen-4-one O-tert-butyl-oxime (example 123B) and 4-(2-chloroethyl) morpholine hydrochloride. The title compound was isolated as a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962627B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-98e2d36bcd654c8db371038d29a42863 |
| Source note | uspto-grants-2015_02 |