HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Chloro-ethyl)-3,3-difluoro-piperidine hydrochloride → 6-[2-(3,3-Difluoro-piperidin-1-yl)-ethoxy]-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one oxime, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Chloro-ethyl)-3,3-difluoro-piperidine hydrochloride | HCID 67192522 | — |
| Reactant | 6-Hydroxy-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one O-tert-butyl-oxime | HCID 86673101 | — |
| Product | 6-[2-(3,3-Difluoro-piperidin-1-yl)-ethoxy]-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one oxime, hydrochloride | HCID 137187584 | — |
Reaction Steps
6-[2-(3,3-Difluoro-piperidin-1-yl)-ethoxy]-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one oxime, hydrochloride was prepared in 67% overall yield using the method described in example 127, starting from 6-Hydroxy-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one O-tert-butyl-oxime (example 127B) and 1-(2-Chloro-ethyl)-3,3-difluoro-piperidine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962627B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-7a978e51ae844293bb55ed99d7422ef9 |
| Source note | uspto-grants-2015_02 |