1-(2-Bromoethyl)-3-(trifluoromethyl)benzene → HCID 86673112, compound

HRID 1853352Notes

Reaction equation

HRID 1853352 reaction equation
C([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[O:10][C:9]([C:18]2[N:23]=[CH:22][N:21]3[CH:24]=[CH:25][CH:26]=[C:20]3[CH:19]=2)=[CH:8]1)(C)(C)C.Br[CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([C:36]([F:39])([F:38])[F:37])[CH:31]=1>>[CH:22]1[N:21]2[CH:24]=[CH:25][CH:26]=[C:20]2[CH:19]=[C:18]([C:9]2[O:10][C:11]3[C:16]([C:7](=[N:6][OH:5])[CH:8]=2)=[CH:15][C:14]([O:17][CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([C:36]([F:37])([F:38])[F:39])[CH:31]=2)=[CH:13][CH:12]=3)[N:23]=1

Participants

3

Reactant 2

HCID 5945351-(2-Bromoethyl)-3-(trifluoromethyl)benzeneHCID 866730736-Hydroxy-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl-oxime

Product 1

HCID 86673112HCID 86673112, compound

Procedure

2-Pyrrolo[1,2-c]pyrimidin-3-yl-6-[2-(3-trifluoromethyl-phenyl)-ethoxy]-chromen-4-one oxime was prepared in 22% overall yield using the method described in example 85, starting from 6-hydroxy-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl oxime (example 81A) and 1-(2-Bromo-ethyl)-3-trifluoromethyl-benzene.

Workup

  1. customoverall yield

Sources & evidence

ORD record
ord-d08b625beac9418c8769059964b29ea7
Source dataset
uspto-grants-2015_02
Patent number
US08962627B2

Reaction notes

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