Hydrochloric Acid → HCID 86673118, compound

Participants

Reaction Steps

To a solution of 4-(tert-Butoxyimino)-2-pyrrolo[1,2-c]pyrimidin-3-yl-4H-chromene-6-carboxylic acid methyl ester (example 115B) (574 mg, 1.46 mmol) in dichloromethane (9 ml) at 0° C. was added a 1M solution of DIBAL-H in THF (12.8 ml). After 2 hours at 0° C. an additional amount of 1M solution of DIBAL-H in THF (6 ml) was added to complete the reaction. After hydrolysis with a 1M aqueous solution of hydrogen chloride, the reaction mixture was extracted with ethyl acetate. The organic layers were washed with water, brine, dried over sodium sulfate, filtered and concentrated. The product was used without further purification.

Provenance & Evidence