3-(3-Chloro-propoxy)-pyridine → HCID 86673122, compound

HRID 1853361Notes

Reaction equation

HRID 1853361 reaction equation
C([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[O:10][C:9]([C:18]2[N:23]=[CH:22][N:21]3[CH:24]=[CH:25][CH:26]=[C:20]3[CH:19]=2)=[CH:8]1)(C)(C)C.Cl[CH2:28][CH2:29][CH2:30][O:31][C:32]1[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=1>>[N:34]1[CH:35]=[CH:36][CH:37]=[C:32]([O:31][CH2:30][CH2:29][CH2:28][O:17][C:14]2[CH:15]=[C:16]3[C:11](=[CH:12][CH:13]=2)[O:10][C:9]([C:18]2[N:23]=[CH:22][N:21]4[CH:24]=[CH:25][CH:26]=[C:20]4[CH:19]=2)=[CH:8][C:7]3=[N:6][OH:5])[CH:33]=1

Participants

3

Reactant 2

HCID 184333433-(3-Chloro-propoxy)-pyridineHCID 866730736-Hydroxy-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl-oxime

Product 1

HCID 86673122HCID 86673122, compound

Procedure

6-[3-(Pyridin-3-yloxy)-propoxy]-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one oxime was prepared in 9% overall yield using the method described in example 147, starting from 6-hydroxy-2-pyrrolo[1,2-c]pyrimidin-3-yl-chromen-4-one O-tert-butyl-oxime (example 81A) and 3-(3-Chloro-propoxy)-pyridine.

Workup

  1. customoverall yield

Sources & evidence

ORD record
ord-c690608eb8a64673918a7361da2e0c1f
Source dataset
uspto-grants-2015_02
Patent number
US08962627B2

Reaction notes

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