4-Piperidinol, 1-(2-pyridinyl)-, 4-methanesulfonate → HCID 136487841, compound

HRID 1853373Notes

Reaction equation

HRID 1853373 reaction equation
C([O:5][N:6]=[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[O:10][C:9]([C:18]2[N:23]=[CH:22][C:21]3[CH:24]=[CH:25][S:26][C:20]=3[CH:19]=2)=[CH:8]1)(C)(C)C.[N:27]1([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][N:39]=2)[CH2:32][CH2:31][CH:30](OS(C)(=O)=O)[CH2:29][CH2:28]1>>[N:27]1([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][N:39]=2)[CH2:32][CH2:31][CH:30]([O:17][C:14]2[CH:15]=[C:16]3[C:11](=[CH:12][CH:13]=2)[O:10][C:9]([C:18]2[N:23]=[CH:22][C:21]4[CH:24]=[CH:25][S:26][C:20]=4[CH:19]=2)=[CH:8][C:7]3=[N:6][OH:5])[CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 106825184-Piperidinol, 1-(2-pyridinyl)-, 4-methanesulfonateHCID 866731016-Hydroxy-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one O-tert-butyl-oxime

Product 1

HCID 136487841HCID 136487841, compound

Procedure

6-(3,4,5,6-Tetrahydro-2H[1,2′]bipyridinyl-4-yloxy)-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one oxime was prepared in 6% overall yield using the method described in example 169, starting from 6-Hydroxy-2-thieno[3,2-c]pyridin-6-yl-chromen-4-one O-tert-butyl-oxime (example 127B) and methanesulfonic acid 3,4,5,6-tetrahydro-2H-[1,2]bipyridinyl-4-yl ester (example 170A).

Workup

  1. customoverall yield

Sources & evidence

ORD record
ord-e47aecc2d4824b6884cc09bf1925ae88
Source dataset
uspto-grants-2015_02
Patent number
US08962627B2

Reaction notes

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