HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1853392Generated: October 31, 2026
Trifluoroacetic acid → HCID 69328147, compound
https://huagongshe.com/reaction/1853392
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | ethyl 1H-pyrazole-4-carboxylate | HCID 142179 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 69328147 | HCID 69328147 | — |
Reaction Steps
To 1.00 g (7.14 mmol) ethyl 4-pyrazolecarboxylate and 0.98 mL (10.7 mml) 3,4-dihydro-2H-pyran an 20 mL THF are added 0.94 mL (12.1 mmol) TFA and the reaction mixture is stirred at 80° C. over night. Afterwards the reaction mixture is diluted with DCM and charged with aq. NaHCO3 solution. The layers are separated and the org. layer is dried over MgSO4, filtered and the solvent is removed in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08962641B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-99540710b57d4db2a50ed65df67c1475 |
|---|
| Source note | uspto-grants-2015_02 |
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