Acetic Anhydride → 4-Oxazolecarboxylic acid, 2-(acetylamino)-, ethyl ester

HRID 1853394Notes

Reaction equation

HRID 1853394 reaction equation
[NH2:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([NH:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1)(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 319549Ethyl 2-amino-1,3-oxazole-4-carboxylate

Product 1

HCID 2153734-Oxazolecarboxylic acid, 2-(acetylamino)-, ethyl ester

Procedure

A mixture of 1 g (6.41 mmol) ethyl 2-aminooxazole-4-carboxylate and 9.1 ml (96.3 mmol) acetic acid anhydride are stirred at r.t. over night. The solvent is removed in vacuo. Toluene is added and evaporated. This procedure is repeated three times.

Workup

  1. customThe solvent is removed in vacuo
  2. additionToluene is added
  3. customevaporated

Sources & evidence

ORD record
ord-ddbc35db6a194b7f926f840b7142d46b
Source dataset
uspto-grants-2015_02
Patent number
US08962641B2

Reaction notes

Loading…