反应详情

3-Amino-2-methyl-4(3H)-quinazolinone and 1-adamantaneacetyl chloride were reacted as described in Example 5 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.60-1.74 (m, 9H), 1.94-1.98 (m, 3H), 2.13 (d, J=1.7 Hz, 1H), 2.39 (s, 3H), 7.50-7.56 (m, 1H), 7.63-7.65 (m, 1H), 7.82-7.88 (m, 1H), 8.11 (dd, J=8.1, 1.0 Hz, 1H), 10.87 (s, 1H) ppm; MS (DCI/NH3) m/z 352 (M+H)+; Elemental Analysis: Calculated for C20H25N3O2.H2O: C, 68.27; H, 7.37; N, 11.37. Found: C, 68.16; H, 7.40; N, 11.40.