3-Amino-2-ethylquinazolin-4(3H)-one → HCID 49872435, compound

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Reaction Steps

3-Amino-2-ethyl-4(3H)-quinazolinone and 1-adamantaneacetyl chloride were reacted as described in Example 5 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.23 (t, J=7.3 Hz, 3H), 1.60-1.74 (m, 12H), 1.92-1.99 (m, 3H), 2.08-2.18 (m, 2H), 2.58-2.79 (m, 2H), 7.50-7.56 (m, 1H), 7.67 (d, J=7.8 Hz, 1H), 7.82-7.88 (m, 1H), 8.12 (dd, J=8.1, 1.4 Hz, 1H), 10.82 (s, 1H) ppm; MS (DCI/NH3) m/z 366 (M+H)+; Elemental Analysis: Calculated for C22H27N3O2.0.75H2O: C, 69.72; H, 7.58; N, 11.09. Found: C, 69.85; H, 7.77; N, 10.98.

Provenance & Evidence