1-Adamantaneacetyl chloride → HCID 49872537, compound

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Reaction Steps

3-Amino-6-chloro-4(3H)-quinazolinone and 1-adamantaneacetyl chloride were reacted as described in Example 5 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.60-1.70 (m, 12H), 1.93-1.98 (m, 3H), 2.10 (s, 2H), 7.78 (d, J=8.7 Hz, 1H), 7.93 (dd, J=8.7, 2.4 Hz, 1H), 8.15 (d, J=2.4 Hz, 1H), 8.25 (s, 1H), 11.18 (s, 1H) ppm; MS (DCI/NH3) m/z 372 (M+H)+; Elemental Analysis: Calculated for C20H22ClN3O2.0.2H2O: C, 63.98; H, 6.01; N, 11.19. Found: C, 3.87; H, 5.85; N, 11.14.

Provenance & Evidence