反应详情

3-Amino-2-isopropyl-4(3H)-quinazolinone and the product of Example 21A were reacted as described in Example 5 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.21-1.26 (m, 6H), 1.51-1.74 (m, 6H), 1.99-2.19 (m, 8H), 2.25 (s, 2H), 3.08-3.17 (m, 1H), 7.51-7.56 (m, 1H), 7.67 (d, J=8.3 Hz, 1H), 7.82-7.88 (m, 1H), 8.13 (dd, J=7.9, 1.6 Hz, 1H), 10.89 (s, 1H) ppm; MS (DCI/NH3) m/z 414 (M+H)+; Elemental Analysis: Calculated for C23H28ClN3O2: C, 66.74; H, 6.82; N, 10.15. Found: C, 66.65; H, 6.82; N, 10.03.