3-Amino-2-isopropyl-4(3H)-quinazolinone → HCID 49872631, compound

HRID 1853410Notes

Reaction equation

HRID 1853410 reaction equation
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[CH:13]([CH3:15])[CH3:14].[Cl:16][C:17]12[CH2:26][CH:21]3[CH2:22][CH:23]([CH2:25][C:19]([CH2:27][C:28](Cl)=[O:29])([CH2:20]3)[CH2:18]1)[CH2:24]2>>[Cl:16][C:17]12[CH2:26][CH:21]3[CH2:22][CH:23]([CH2:25][C:19]([CH2:27][C:28]([NH:1][N:2]4[C:11](=[O:12])[C:10]5[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=5)[N:4]=[C:3]4[CH:13]([CH3:15])[CH3:14])=[O:29])([CH2:20]3)[CH2:18]1)[CH2:24]2

Participants

3

Reactant 2

HCID 51882113-Amino-2-isopropyl-4(3H)-quinazolinoneHCID 86648157HCID 86648157, compound

Product 1

HCID 49872631HCID 49872631, compound

Procedure

3-Amino-2-isopropyl-4(3H)-quinazolinone and the product of Example 21A were reacted as described in Example 5 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.21-1.26 (m, 6H), 1.51-1.74 (m, 6H), 1.99-2.19 (m, 8H), 2.25 (s, 2H), 3.08-3.17 (m, 1H), 7.51-7.56 (m, 1H), 7.67 (d, J=8.3 Hz, 1H), 7.82-7.88 (m, 1H), 8.13 (dd, J=7.9, 1.6 Hz, 1H), 10.89 (s, 1H) ppm; MS (DCI/NH3) m/z 414 (M+H)+; Elemental Analysis: Calculated for C23H28ClN3O2: C, 66.74; H, 6.82; N, 10.15. Found: C, 66.65; H, 6.82; N, 10.03.

Sources & evidence

ORD record
ord-1aba8e0a1cec4496beab70754e3ca846
Source dataset
uspto-grants-2015_02
Patent number
US08962639B2

Reaction notes

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