HCID 660173, compound → HCID 49872635, compound

Participants

Reaction Steps

3-Amino-2-phenoxymethyl-4(3H)-quinazolinone and 1-adamantaneacetyl chloride were reacted as described in Example 5 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.50-1.64 (m, 9H), 1.84 (br s, 3H), 2.03-2.15 (m, 2H), 4.96-5.07 (m, 2H), 6.94-7.03 (m, 3H), 7.27-7.34 (m, 2H), 7.59-7.64 (m, 1H), 7.72 (d, J=7.8 Hz, 1H), 7.87-7.92 (m, 1H), 8.18 (dd, J=8.0, 1.2 Hz, 1H), 10.91 (s, 1H) ppm; MS (DCI/NH3) m/z 444 (M+H)+; Elemental Analysis Calculated for C27H29N3O3.H2O: C, 70.26; H, 6.77; N, 9.10. Found: C, 70.17; H, 6.71; N, 9.23.

Provenance & Evidence