3-amino-7-chloro-2-methylquinazolin-4(3H)-one → HCID 49872727, compound

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Reaction Steps

3-Amino-7-chloro-2-methylquinazolin-4(3H)-one and 1-adamantaneacetyl chloride were reacted as described in Example 5 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.59-1.74 (m, 12H), 1.93-1.98 (m, 3H), 2.08-2.18 (m, 2H), 2.40 (s, 3H), 7.57 (dd, J=8.5, 2.0 Hz, 1H), 7.72 (d, J=1.7 Hz, 1H), 8.11 (d, J=8.8 Hz, 1H), 10.90 (s, 1H); MS (DCI/NH3) m/z 386 (M+H)+; Elemental Analysis: Calculated for C21H24ClN3O2.H2O: C, 62.45; H, 6.49; N, 10.40. Found: C, 62.63; H, 6.27; N, 10.36.

Provenance & Evidence